Coronavirus belongs to Coronaviridae family, order Nidovirales, cause a broad spectrum of animal and human diseases. Coronaviruses have distinctive morphology, the name derived from the outer fringe, or envelope protein. Replication of the RNA genome proceeds through a nested set of viral mRNA molecules. In 2003, Coronavirus causing mild upper respiratory tract SARS-CoV infections and recently emergence of MERS-CoV has confirmed, the coronaviruses as remarkably causes of severe respiratory disease.